Statins May Increase Intracerebral Hemorrhage Volume
نویسندگان
چکیده
منابع مشابه
Management of intracerebral hemorrhage–use of statins
Intracerebral hemorrhage (ICH) is a neurologic injury resulting in significant morbidity and mortality. Statins play a significant role in primary and secondary prevention of cardiovascular and cerebrovascular ischemic events. Despite clear benefits of statins in ischemic stroke, post hoc analyses of some studies suggest there may be a link between statin therapy and development of ICH. Direct ...
متن کاملStatins and intracerebral hemorrhage: collaborative systematic review and meta-analysis.
BACKGROUND A recent large, randomized trial suggested that statins may increase the risk of intracerebral hemorrhage. Accordingly, we systematically reviewed the association of statins with intracerebral hemorrhage in randomized and observational data. METHODS AND RESULTS We screened 17 electronic bibliographic databases to identify eligible studies and consulted with experts in the field. We...
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OBJECTIVE 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been associated with improved clinical outcomes after ischemic stroke and subarachnoid hemorrhage, but with an increased risk of incidental spontaneous intracerebral hemorrhage (ICH). We investigated whether the statin use before ICH, was associated with functional independence, 90 days after treatm...
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BACKGROUND A recent post hoc analysis of a large randomized trial in patients with cerebrovascular disease suggested that statins may increase the risk of intracerebral hemorrhage (ICH). OBJECTIVE To examine the association between statins and ICH in patients with recent ischemic stroke in a population-based setting. DESIGN Retrospective propensity-matched cohort study with accrual from Jul...
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BACKGROUND AND PURPOSE Apolipoprotein E (ApoE) genotypes have been associated with lobar intracerebral hemorrhage (ICH). Although statins have been associated with an increased risk of ICH, meta-analyses have not consistently shown a statin-induced risk of ICH. Here, we test whether hypercholesterolemia (HC) and ApoE polymorphisms affect the risk of ICH by statin use. METHODS The Genetic and ...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 2010
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100051453